Modern crop breeding is entering a new era of genome design, led by genome editing technologies as mainstream tools for targeted genome modification. In a review published in Nature Reviews Genetics, ...

Genome editing is a powerful biotechnology tool that allows scientists to make precise changes to an organism's DNA. It involves the use of specialized enzymes, known as engineered nucleases or ...

The prime editor is a fusion protein consisting of a catalytically impaired Cas9 nickase (Cas9n) and an engineered reverse transcriptase (RT). The Cas9n is guided by a prime editing guide RNA (pegRNA) ...

The Human Genome Project changed everything. A map of the entire human sequence of DNA was the starting point for an enormous number of discoveries, from disease genes to how humans evolved. But DNA ...

A committee-supported project or activity that has been completed and for which output dissemination has begun. Its committee has been disbanded and closeout procedures are underway. An ad hoc ...

A team of Chinese researchers has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems. The study, published online in Cell on August ...

The discovery of CRISPR-Cas9’s gene-editing prowess revolutionized genetic engineering just over a decade ago. Now it appears that genetic engineering technology may be taking its next big leap.

Over millennia, there has been a seamless continuum of technologies for genetic modification of plants, animals, and microorganisms, with progressive improvements in precision and predictability – a ...

Genetic regulation of glucose homeostasis is central to the maintenance of human health and the prevention of metabolic disorders such as type 1 and type 2 diabetes. Recent advances in molecular ...

Hepatitis C virus (HCV) infections are associated with the risk of progression to fibrosis, cirrhosis, and hepatocellular carcinoma. The HCV RNA genome is translated by an internal ribosome entry site ...