Silencing mediated by Polycomb repressor complexes (PRCs) in embryonic stem cells (ESCs) can be accompanied by histone marks typical of active genes and RNA polymerase II (RNAPII) presence. A study by ...

In tumor samples, the RNAPII enzyme signals found on histone genes were reliably able to distinguish between cancer and normal samples. RNAPII signals on histone genes also correlated with clinical ...

Some long noncoding RNAs (ncRNAs) transcribed by RNA polymerase II (RNAPII) are retained on chromatin, where they regulate RNAi and chromatin structure. The molecular basis of this retention remains ...

Hyper-elevated levels of RNAPII on these histone genes indicate cancer over-proliferation and potentially contribute to chromosomal changes. These findings point to the use of a new genomic technology ...

Rpb1, the largest subunit of RNA polymerase II (RNAPII), is rapidly polyubiquitinated and degraded in response to DNA damage; this process is considered to be a “mechanism of last resort” employed by ...

RNA polymerase II (RNAPII) initiates transcription at a multitude of positions in the human genome. However, only a fraction of these sites is associated with genes that give rise to functional RNA.

Using a new technology and computational method, researchers from Fred Hutch Cancer Center and The University of Texas MD Anderson Cancer Center have uncovered a biomarker capable of accurately ...

Similar to the way expanding companies increase their work forces, cells must boost their production of internal biomolecules when they grow in size in order to stay healthy. In the 1970s, biologists ...